For Mind, Mood, Mental Clarity, Immunity & Sleep
MultiShroom™ is a special blend of mushrooms and natural vegetable source minerals creating a synergy of ingredients that offers a multitude of benefits and helps to support brain function, mental clarity, immune function, mood elevation and stress reduction.
MultiShroom™ is produced with a natural mechanical delivery system and suspended in liquid allowing for much more efficient and much greater bioavailability and absorption than a standard capsule or tablet product.
Here are the naturally occurring ingredients as found in our MultiShroom™ product and their benefits:
Chaga (Inonotus obliquus) is not strictly a mushroom, but rather a unique fungus that is similar to mushroom and is mainly found growing on birch trees.
Chaga is a traditional Native American medicine that has been used for centuries.
Here are some of the benefits related to Chaga use:
- Support cardiovascular health
- Support immune health
- Maintain blood sugar already within healthy limits
- Enhance liver, stomach, and skin health
- Counteract tiredness
- Enable free and easy breathing
- Encourage a healthy inflammation response
- Support purification of the blood
Many experience Chaga as an essential part of their immune-supporting protocols and use it daily for that reason.
Here are some additional details on the primary benefits of Chaga:
1. Antioxidant Boost
Severe oxidative stress can lead to damage to components of the cell (including DNA), cell death (also known as apoptosis), and disruptions in cellular signaling. Oxidative stress is known to be involved in aging and in the development of many age-related ailments and conditions. Antioxidants like Chaga can help to prevent oxidative stress.
Chaga produces an impressive array of metabolites capable of acting as potent free radical scavengers. The metabolites in chaga can protect DNA from being damaged by oxidative stress. One study demonstrated that cells pretreated with chaga mushroom extracts before being treated with the free radical H2O2 showed 40% less DNA damage than those that weren’t pretreated.
Chaga ORAC Value:
Chaga is also considered to be very high on the ORAC scale, which is a measurement of antioxidant power and some websites have claimed Chaga is the highest of any food.
Chaga is a powerhouse of trace minerals like zinc, copper, iron, and manganese, which can stimulate the production of SOD’s which stands for superoxide dismutase. SOD’s are enzymes that form the first line of antioxidant defense against damage caused by free radicals
Chaga has been traditionally used to encourage gastrointestinal health and digestive comfort. Modern research confirms that it has gastroprotective properties and helps regulate the gut microbiota.
Extracts of chaga helped protect the integrity of the stomach wall when given to rats at 200 mg/kg. In another study, mice were fed chaga extracts at 50 and 100 mg/kg body weight. The results showed that by regulating the release of cytokines, chaga supported the health of the colonic mucosa.
The antioxidant activity of polysaccharides in chaga was also found to support pancreatic health and regulate gut microbiota composition and diversity in mice.
Chaga has been used traditionally for centuries to alleviate gastrointestinal discomfort, and modern science is confirming the potential of chaga to promote gut health.
You may have read or heard the term “adaptogen” or biological response modifier (BRM) in reference to certain herbs and functional mushrooms. As the name implies, BRMs are substances that can modulate the immune system’s response, by either turning it up or down.
An adaptogen is a type of BRM that must meet three criteria:
It must be nonspecific (its effect must be general) and must be able to assist the body in handling a wide range of stressors.
It must be able to help maintain the body’s homeostasis (balance).
It must not harm the normal functions of the body
Essentially, adaptogens help your body adapt to stress and restore balance. And with its rich polysaccharide content, chaga is considered a highly effective adaptogen.
Chaga is an Immune System Adaptogen.
While the immune system is designed to protect the body against foreign invaders, it can also overreact to harmless substances. Such a response can affect the eyes, sinuses, and lungs.
Allergies aren’t always harmless though. Some individuals may experience anaphylactic shock, a severe, and sometimes life-threatening allergic reaction.
As an adaptogen, chaga can help balance an overactive immune system.
Initidiol, a triterpenoid active unique to chaga, acts as a mast cell stabilizer and can support eye and nasal comfort. Chaga can promote the secretion of certain cytokines to modulate immune responses. An animal study also showed that chaga mushroom extracts prevented chemically-induced immune system overreactions, demonstrating its potential as a useful adaptogenic functional food.
Studies have shown that the active compounds in chaga may have selective activity against many types of malignant cells.
5. Blood Sugar Balancing
Insulin is the hormone responsible for moving glucose in the bloodstream into your muscle and fat cells, where it is stored for energy production.
Healthy blood sugar levels are linked to heart, blood vessel, nerve, kidney, skin, and brain health.
Chaga and Blood Glucose Levels:
Multiple animal studies suggest that chaga may be able to support balanced blood sugar levels. In one study, investigators found that mice fed chaga extract for three weeks were better able to maintain healthy blood glucose levels as well as total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C, “bad cholesterol”) levels. Most notably, the research team found that feeding chaga supported healthy pancreatic tissue in the mice (the pancreas is the organ that secretes insulin).
A follow-up study confirmed these effects on blood sugar and cholesterol. Mice treated with either 30 or 60 mg/kg body weight of chaga ethanol extract for 21 days had similar results as in the first study.
Part of chaga’s effects on blood sugar may be attributed to the inhibition of an enzyme that breaks down starch by its polysaccharides. Blocking this enzyme helps slow down glucose absorption in the digestive organs. Research performed in vitro showed the polysaccharides in chaga inhibit this enzyme.
6. Muscle Fatigue
The polysaccharides in chaga mushroom continue to surprise scientists with their benefits. Chaga is an adaptogen: it has the capacity to bring balance to your entire body, including your energy levels and muscle endurance.
A study showed that chaga may help increase exercise endurance. Subjects were given chaga extracts for 14 days (at 0, 100, 200 and 300 mg/kg) and were able to swim for a longer period of time than those given distilled water. Scientists noted that the subjects given chaga also had significantly more glycogen — the predominant storage form of glucose for energy production — in their liver and muscles. Glycogen storage directly affects exercise endurance, and the results of this study suggest that chaga might increase the time before glycogen is depleted.
Chaga polysaccharides also greatly reduced blood lactate levels in the subjects. Muscles produce high levels of lactate during high-intensity exercise, which contributes to fatigue. Therefore, removing lactate quickly is beneficial to prevent or delay fatigue.
Chaga is showing great potential as a supplement for athletic endurance: recent studies demonstrate its capacity to increase the storage of glycogen in muscles and to decrease blood lactate levels, leading to less muscle fatigue.
7. Supporting Immunity
As a traditional remedy, chaga extracts have been used to enhance immune system function.
The immune-supporting activity is believed to be due to the diverse bioactive compounds found in chaga, like betulin, hispolon, hispidin, lupeol, and mycosterols.
Betulinic acid, which is unique to chaga, and chaga’s other bio-compounds are being investigated by the scientific community as potential agents to protect the body against a variety of foreign invaders.
8. Skin Repair and Protection
Beta-glucans and betulinic acid in chaga may help slow down signs of aging in your skin.
Chaga infusions have been used to comfort irritated skin and reduce redness and dryness. A case study of 50 participants found that after taking chaga for 9 to 12 weeks, individuals experienced improved skin health, as demonstrated by increased skin comfort, smoothness, and moisturization.
Melanin also plays an important role in skin health. Melanin, like that found in chaga, is thought to protect human skin against DNA damage by absorbing UV radiation. One in vitro study found that melanin increased the sun protection factor (SPF) of gel sunscreens. Another study found that melanin functions as a free radical scavenger, which can also help keep your skin looking younger for longer.
9. Brain Function Enhancement
Oxidative stress is a major contributor to mild memory problems associated with aging.
A team of researchers investigated if chaga had any protective effects in subjects with chemically-induced cognitive decline. They found that those subjects given chaga for 7 days had significantly improved learning and memory compared to those that did not receive the fungus.
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Lion’s Mane mushroom:
Lion’s Mane (Hericium erinaceus) is known as the “Mind” mushroom. Lion’s Mane has been used traditionally for thousands of years to support healthy brain functioning and neuron regeneration of nerve tissues.
Lion’s Mane is rich in beta-glucans, which are responsible for antitumor growth, immuno-modulating antioxidants and neuro-protective compounds in the body. Oxidative stress, which these compounds protect against, is closely related to the pathogenesis of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Nerve Growth Factor (NGF) synthesis in nerve cells may be induced by certain compounds (hericenones and erinacines) as found in Lion’s Mane which makes it an amazing supporter for the function of brain cells and other nerves as found in all parts of the body.
Here are some of the main health benefits of Lion’s Mane:
1. Memory Support: Lion’s Mane Mushrooms are renowned for helping to support cognitive functions, such as memory. Studies have shown that Lion’s Mane Mushrooms may have the potential to improve symptoms of dementia, as it can prevent neuronal damage caused by amyloid-beta plaques, which may accumulate in the brain over time.
Lion’s Mane Mushrooms have the ability to help reduce brain fog and improve memory through two essential compounds known as hericenones and erinacines. These compounds directly act in your hippocampus and a result, they can regenerate the neural links and build new neurons. Lion’s Mane Mushrooms also have the ability to decrease inflammation, which is associated with conditions known to cause brain fog.
2. Stress Relief: Through its antioxidant properties, Lion’s Mane Mushrooms have proven to be very useful to aid in the reduction of stress and create tranquility in the body and mind. Several early studies have found that Lion’s Mane decreased inflammation and oxidative stress and may be particularly beneficial to help control inflammatory bowel disease, liver damage, and stroke.
3. Repair Nerve Damage: Studies have shown that Lion’s Mane Mushrooms can build and repair neuronal pathways, synapses, and neurons within the brain. In turn, making your mind sharper and speeding up the process of repairing nerve damage anywhere in the body. There are very few things that can repair nerve damage or rejuvenate nerve tissues. Lion’s Mane offers amazing support of regenerative nervous system health.
A study in 2011 showed an increased rate of recovery after peripheral nerve injury in those who took Lion’s Mane Mushroom extract versus those who did not. Study results showed that those who took Lion’s Mane Mushroom extract began to see improvement by day four, while those who did not still saw no signs of improvement during the same timeframe. By day 14, those who took Lion’s Mane Mushroom had a 50% improvement rate and a more comprehensive recovery than the group that had not.
4. Reduction of Anxiety and Depression Symptoms: Lion’s Mane Mushrooms are rich in antioxidants and anti-inflammatory properties, both of which produce a combined effect to potentially reduce anxiety and symptoms of depression.
In a 2015 study, subjects that consumed Lion’s Mane Mushroom extract had fewer depressive symptoms. This, according to the researchers, is due to the extract’s anti-inflammatory properties. The findings of a 2018 study back this up, with the authors concluding that Lion’s Mane may contain agents useful for treating depression.
Another study reveals that Lion’s Mane Mushrooms may aid with depression and anxiety. For the trial, 30 menopausal women ate either Lion’s Mane Mushroom or a placebo cookie every day for four weeks. According to the findings of this study, women in the Lion’s Mane Mushroom group were less irritated and anxious, and they had less difficulty concentrating than those in the placebo group.
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Cordyceps mushroom (Cordyceps sinensis) is a traditional, natural Asian medicine that has been used for many centuries and the beneficial effects of its use are well known.
Here are some of the health benefits of Cordyceps:
1. Increased Energy and Performance: Cordyceps contains Cordycepin, an active compound known for its ability to improve oxygen absorption and to support the production of ATP which provides energy within the cells. Cordyceps supports increased energy levels and improved athletic performance. One study has indicated that there is close to a 50% increase in cellular energy levels after supplementing with Cordycepin as contained in Cordyceps. In the 1993 Olympics, many Chinese runners shattered world records after supplementing with Cordyceps.
2. Improved Heart Health: Heart disease is currently the leading cause of death in the United States, with nearly 650,000 people dying from it every year. So, taking preventative measures to strengthen your cardiovascular system is essential for your long-term health. Cordyceps has been shown to support the lowering of LDL cholesterol and triglyceride levels, which contributes to a healthier cardiovascular system. Also, Cordyceps contains many antioxidants to support heart health and function.
3. Anti-Malignancy Properties: The compound Cordycepin has shown an amazing ability to support the attack of tumors and abnormal cell growths in the body. A recent lab test showed that Cordycepin applied to tumors resulted in them shrinking in size. It’s currently hypothesized that supplementing with Cordyceps could help the body prevent certain cancers from even starting to form in the first place. Cordycepin works on cancer cells by disrupting their ability to create the vital proteins they need to survive, leading to cancer cell death.
4. Supporting Immune Functions: Cordyceps contain many beneficial amino acids, vitamins, minerals, and polysaccharides that improve the body’s natural defense system. It also provides powerful anti-fungal, anti-viral, and antibacterial properties. Cordyceps help stimulate the production of NK cells (Natural Killer cells), which are an integral part of the immune system’s defense against pathogens, infection, and illness.
5. Supports healthy Liver and Kidney Function: Cordyceps is commonly used to treat kidney disease in Asian countries by helping to protect the kidneys from oxidative stress, inflammation, and improving kidney function. A 2014 study found that Cordyceps achieved this by regulating the levels of metabolites that become imbalanced from chronic kidney disease (CKD), improving liver and kidney function in the process. In addition, Cordyceps has been shown to stimulate the liver and support detoxification processes within the body.
1. Earth Pulse, Ancient Cordyceps in the Modern World
2. HCP Now, Cordyceps Boosts Energy Naturally
3. National Center for Biotechnology Information, Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial
4. National Center for Biotechnology Information, Lipid-lowering effect of cordycepin (3′-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats
5. National Center for Biotechnology, Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris
6. Research Gate, Cordyceps Militaris Enhances Cell-Mediated Immunity in Healthy Korean Men
7. National Center for Biotechnology Information, Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
The Reishi mushroom (Ganoderma lucidum) is a famous and traditional mushroom known as the elixir of long life. It has been a mainstay of Asian medicine for thousands of years and has many health benefits.
Here are some of the main health benefits of Reishi mushroom:
1. Supports stress reduction: Reishi is known for its calming, anti-stress effect. It has shown to be effective at relieving anxiety and depression, as well as helping to lower blood pressure. Reishi is a strong adaptogen that supports adrenal functioning. This allows for relief of stress, fatigue and better cognitive functioning.
2. Supports Immune Function: Reishi has been clinically proven to have a positive impact on production of white blood cells important for immune system function and immune response. This includes a potent anti-inflammatory effect that increases your body’s ability to deal with pathogens, viruses, and stress. Reishi’s high concentration of beta-glucans help to create a very significant immune-boosting effect. Reishi also promotes the development of B and T lymphocytes which are immune cells that are vital for the production of antibodies and the overall regulation of immune system functioning.
3. Anti-Malignancy Properties: A 2010 study related Reishi’s anti-cancer effect to a compound called ganoderic acid, which is a triterpenoid active compound found in the mushroom that attacks the development and metastasis of tumors.
4. Inflammation reduction: The rich antioxidant profile of Reishi helps to reduce inflammation throughout the body, lowering oxidative stress and ensuring that your bio-systems are receiving maximum support for optimal health.
5. Helps support sleep and reduce Insomnia: Reishi can provide a calming effect which supports your healthy sleep patterns.
1. National Center for Biotechnology Information, Ganoderma Lucidum (Lingzhi or Reishi)
2. National Center for Biotechnology Information,Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial
3. National Center for Biotechnology Information,Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain
4. National Center for Biotechnology Information, Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
5. Life Extension Magazine, Fight Immune Decline with Reishi
6. Science Direct,Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression mushroom:
Shitake mushroom (Lentinula edodes) is a well known traditional Asian food ingredient and medicine used world-wide for many years.
Shiitake mushrooms originally grew wild on fallen trees in Japanese forests. Today, they are commercially grown on synthetic logs or in bags of nutrient-enriched sawdust.
Shitake is valued for its earthy flavor and its impressive nutritional profile. Rich in choline, copper, potassium, vitamin D, and zinc, shiitake mushrooms also boast all eight essential amino acids found in meats.
Shiitake provides a wealth of compounds responsible for the mushroom’s medicinal benefits. These include the polysaccharide lentinan, eritadenine, water-soluble lignins, centinamycins A and B, beta glucans, alpha-1,4-glucan oligosaccharides, and triterpenes.
Here are some benefits offered by Shiitake mushrooms:
1. Supports immune function: Shiitake mushrooms possess antioxidant, anti-inflammatory, anti-microbial, and antiviral properties that support a healthy immune response. For example, the lentinan active compound as found in shiitakes protect against a variety of bacterial, viral, and parasitic infections. The centinamycins actives have been shown to boast antibacterial benefits and the eritadenine actives possess antiviral properties. In addition, the lignins from the mushroom’s fruiting bodies (mycelium) have antiviral and immunomodulating effects. One four-week trial involving 52 healthy volunteers between the ages of 21 and 41 found that consuming dried shiitake mushrooms daily improved their gut immunity. Specifically, blood samples found that the mushrooms increased the production of two important types of T-cells—yó-T and natural killer (NK) cells. The researchers also noted an increase in tumor necrosis factor-alpha (TNF-a)—a cell signaling protein involved in inflammation—and IL-4, IL-10, and IL-1a—interleukins that modulate immunity. A recent study found that a standardized form of supplemental shiitake also plays a regulatory role in the body’s immune response, especially NK cells and other T cells.
2. Promotes heart health Shiitake mushrooms help improve cardiovascular health by addressing several common risk factors for heart disease. Animal studies have found that shiitake mushrooms lower low-density lipoprotein (LDL- “bad” cholesterol) levels thanks to three compounds found in the fungi, which include: Beta-glucan, a type of fiber that interacts with cholesterol in the bowel to lower cholesterol levels, Eritadenine, which inhibits the metabolism of cholesterol in the liver and Sterols, which compete with dietary cholesterol so less is absorbed by the small intestine. Shiitake mushrooms have also been found to reduce triglyceride levels by as much as 55%. The bioactive compounds in shiitake mushrooms may also directly help to prevent atherosclerosis. Preliminary studies have found that the compounds in shiitakes inhibit the accumulation of cholesterol, calcium, fibrin, and cellular debris in artery walls. This, in turn, helps to prevent the buildup of arterial plaque that can narrow and stiffen arteries.
3. Supports healthy bones As a result of the vitamin D present in mushrooms like shiitakes bone strength is supported by aiding in the absorption of calcium and inhibiting bone resorption. One cell study found that shiitakes helped to inhibit osteoclast activity (the action of breaking down bone). The study also found that shiitake increased bone mineralization and the production of a bone building compound known as osteocalcin.
4. Supports healthy gums There is evidence that the anti-microbial and anti-inflammatory properties of shiitake mushrooms improve dental health. British researchers have reported that the antibacterial compounds in a shiitake extract reduce harmful bacteria that causes gingivitis. Another study that appeared in the journal Pharmacognosy Review found that these same compounds inhibit plaque-building bacteria that can lead to cavities
5. Supports weight management: The eritadenine active and the beta-glucan compounds as found in shiitake mushrooms may support healthy weight. Studies have found that subjects fed a diet high in shiitake mushrooms had 35% less weight gain than those eating a diet low in the fungi. More recent research suggests that the antioxidant and anti-inflammatory properties in shiitake and other medicinal mushrooms help protect against obesity-related conditions like high cholesterol and metabolic syndrome.
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7. Guillamón, E., García-Lafuente, A., Lozano, M., D/Arrigo, M., Rostagno, M.A. Villares, A., & Martínez, J.A. (2010). Edible mushrooms: role in the prevention of cardiovascular diseases. Fitoterapia, 81(7), 715-723.
8. Hanada, K. & Hashimoto, I. (1998). Flagellate mushroom (shiitake) dermatitis and photosensitivity. Dermatology, 197(3), 255-257.
9. Handayani, D., Chen, J., Meyer, B.J., & Huang, X.F. (2011). Dietary Shiitake mushroom (Lentinus edodes) prevents fat deposition and lowers triglyceride in rats fed a high fat diet. Journal of Obesity, 2011, 258051.
10. Jones, P.J.H., Shamloo, M., MacKay, D.S., Ridgout, T.C., Myrie, S. B., Plat, J., Roullet, J., . . . Weingartner, O. (2018). Progress and perspectives in plant sterol and plant stanol research. Nutrition Reviews, 76(10), 725-746.
11. Kim, S.H., Thomas, M.J., Wu, D., Carman, C.V., Ordovás, J.M., & Meydani, M. (2019). Edible mushrooms reduce atherosclerosis in Ldlr-/- mice fed a high-fat diet. Journal of Nutrition, 149(8), 1377-1384.
12. Leatham, G.F. (1982). Cultivation of shiitake, the Japanese forest mushroom, on logs: a potential industry for the United States. Forest Products Journal, 32(8), 29-35.
13. Lee, K., Morris-Natschke, S.L., Yang, X., Huang, R., Zhou, T., Wu, S., Shi, Q., & Itokawa, H. (2012). Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. Journal of Traditional and Complementary Medicine, 2(2), 84-95.
14. Levy, A.M., Kita, H., Phillips, S.F., Dyer, P.D., Gleich, G.J., & Dubravec, V.A. (1998). Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. The Journal of Allergy and Clinical Immunology, 101(5), 613-620.
15. Mushroom, shiitake, cooked, without salt. FoodData Central. U.S. Department of Agriculture. https://fdc.nal.usda.gov/fdc-app.html#/food-details/168437/nutrients
16. Rahman, M.A., Abdullah, N., & Aminudin, N. (2018). Lentinula edodes (shiitake mushroom): an assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences, 25(8), 1515-1523.
17. Royse, D.J., Schisler, L.C., & Diehle, D.A. (1985). Shiitake mushrooms consumption, production, and cultivation. Interdisciplinary Science Review, 10(4), 329-335.
18. Shin, M.S., Park, H., Maeda, T., Nishioka, H, Fujii, H., & Kang, I. (2019). The effects of AHCC®, a standardized extract of cultured Lentinura edodes mycelia, on natural killer and T cells in health and disease: reviews on human and animal studies. Journal of Immunology Research, 2019, 3758576.
19. Sima, P., Vannucci, L., & Vetvicka, V. (2018). β-glucans and cholesterol. International Journal of Molecular Medicine. 41(4), 1799-1808.
20. Simon, R.R., Borzelleca, J.F., DeLuca, H.F., & Weaver, C.M. (2013). Safety assessment of the post-harvest treatment of button mushrooms (Agaricus bisporus) using ultraviolet light. Food and Chemical Toxicology, 56, 278-289.
21. Stephany, M.P., Chung, S., Handler, M.Z., Handler, N.S., Handler, G.A., & Schwartz, R.A. (2016). Shiitake mushroom dermatitis a review. American Journal of Clinical Dermatology, 17, 485-489.
22. Yang, H., Hwang, I., Kim, S., Hong, E., & Jeung, E. (2013). Lentinus edodes promotes fat removal in hypercholesterolemic mice. Experimental and Therapeutic Medicine, 6(6), 1409-1413.
23. Yu, S., Wu, X., Ferguson, M., Simmen, R.C.M., Cleves, M.A., Simmen, F.A. & Fang, N. (2016). Diets containing shiitake mushrooms reduce serum lipids and serum lipophilic antioxidant capacity in rats. The Journal of Nutrition, 146(12), 2491-2496.
24. Zembron-Lacny, A., Gajewski, M., Naczk, M., & Siatkowski, I. (2013). Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. Journal of Physiology and Pharmacology, 64(2), 249-254.
Maitake mushrooms (Grifola frondosa) are a traditional food and medicine used for thousands of years.
Maitake mushrooms health benefits:
1. Anti-Malignancy support: We know that tumors are of two types- benign and malignant. Maitake mushrooms serve as a potential source of nutrients and minerals required to fight the conditions that lead to tumors or malignant tissues.
2. Antiviral support: The most common cause of diseases these days are viruses. Contagious viruses are capable of entering the host’s body. The amelioration of common health conditions like cough, cold, caused by flu viruses may be helped with the consumption of Maitake.
3. Blood pressure Balancing: Maitake has been shown to help support normal blood pressure levels.
4. Energy support: Maitake mushrooms are abundant in fatty acids and these compounds are broken down to form ATP by your bodies’ metabolism. ATP is a main source of energy in the human body.
5. Supports cholesterol regulation: Maitake mushrooms help to promote a healthy and balanced cholesterol environment within the body. 5. Blood sugar balancing: The ability of Maitake mushrooms to help maintain healthy functioning of type-2 diabetes, a blood sugar imbalance, affected individuals has been scientifically proven.
6. Supports healthy Immunity: Maitake mushrooms are a perfect combination of health and taste. When you delve deep into the healthy properties, you will surely get to know that Maitake mushrooms contain amounts of potassium, calcium, magnesium, amino acids, fibers, and vitamins like vitamin B2, D, and others. This combination corresponds to an overall positive impact on the body and serves to prevent nutrient deficiencies within the body which helps the immune system perform efficiently.
1. Hobbs C. Medicinal Mushrooms, 3rd ed. Loveland (CO): Interweave Press; 1996.
2. Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull 1987;35:262-70.
3. Kubo K, Aoki H. Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). Biol Pharm Bull 1994;17:1106-10.
4. Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol 2001;47:57-63.
5. Kodama N, Komuta K, Nanba H. Can Maitake MD-fraction aid cancer patients? Altern Med Rev 2002;7:236-9.
6. Miura NN. Blood clearance of (1—>3)-beta-D-glucan in MRL lpr/lpr mice. FEMS Immunol Med Microbiol 1996;13:51-7.
7. Ohno N, et al. Characterization of the antitumor glucan obtained from liquid-cultured Grifola frondosa. Chem Pharm Bull 1986;34:1709-1715.
8. Nanba H, Kubo K. Maitake D-fraction: Healing and preventive potential for cancer. J Orthomolecular Med 1997;12:43-9.
9. Konno S, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001 Dec;18(12):1010
10. Yamada Y, et al. Antitumor effect of orally administered extracts from the fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790-6.
11. Lin H, et al. Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. Int Immunopharmacol 2004 Jan;4(1):91-9.
12. Hong L, Xun M, Wutong W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. Pharm Pharmacol. 2007 Apr;59(4):575-82.
13. Masuda Y, Murata Y, Hayashi M, Nanba H. Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells. Biol Pharm Bull 2008 Jun;31(6):1104-8.
14. Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21
15. Harada N, Kodama N, Nanba H. Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice. Cancer Lett. 2003;192(2):181-7.
16. Shomori K, Yamamoto M, Arifuku I, Teramachi K, Ito H. Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines. Oncol Rep. 2009 Sep;22(3):615-20.
17. Lin H, de Stanchina E, Zhou XK, et al. Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity. Cancer Immunol Immunother. 2010 Jun;59(6):885-97.
18. Louie B, Rajamahanty S, Won J, Choudhury M, Konno S. Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells. BJU Int. 2010 Apr;105(7):1011-5.
19. Lee JS, Park SY, Thapa D, et al. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. Exp Mol Med. 2010 Feb 28;42(2):143-54.
20. Masuda Y, Ito K, Konishi M, Nanba H. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother. 2010 Oct;59(10):1531-41.
21. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother. 2010 Jan;44(1):223-4.
22. Chen JT, Tominaga K, Sato Y, Anzai H, Matsuoka R. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med. 2010 Dec;16(12):1295-9.
23. Soares R, Meireles M, Rocha A, et al. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.J Med Food. 2011 Jun;14(6):563-72.
24. Fang J, Wang Y, Lv X, et al. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J. 2012 Aug;29(5-6):365-77.
25. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. (2015) 64:237–247 DOI 10.1007/s00262-014-1628-6
26. Roldan-Deamicis A, Alonso E, Brie B, Braico DA, Balogh GA. Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice. Cancer Med. 2016 Sep;5(9):2427-41.
27. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. Int J Mol Med. 2017 Oct;40(4):1089-1095.
28. Masuda Y, Nakayama Y, Tanaka A, Naito K, Konishi M. Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor. PLoS One. 2017 Mar 9;12(3):e0173621.
29. Bao H, Ran P, Sun L et al. Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice. Pharm Biol. 2017 Dec;55(1):299-305.
30. Mao G, Li Q, Deng C, et al. The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice. Int J Biol Macromol. 2018 Feb;107(Pt B):2211-2216.
31. Zhao F, Zhao J, Song L, Zhang YQ, Guo Z, Yang KH. The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis. 2017 Nov;22(11):1461-1472.
32. Sultana SS, Ghosh J, Chakraborty S, et al. Selective in vitro inhibition of Leishmania donovani by a semi-purified fraction of wild mushroom Grifola frondosa. Exp Parasitol. 2018 Sep;192:73-84.
33. Meng M, Guo M, Feng C, Wang R, Cheng D, Wang C. Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways. Food Funct. 2019 Aug 1;10(8):4998-5007.
34. Li L, Guo WL, Zhang W, et al. Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats. Food Funct. 2019 May 22;10(5):2560-2572.
Natural source of Fulvic and Humic acids From Mineral Pitch:
MultiShroom™ contains natural plant-source Fulvic and Humic acids from Mineral Pitch which is a plant-based natural gum as found in ancient mountainous granite formations.
Because of our depleted soils, Fulvic and Humic acids that are necessary for our optimal health have virtually disappeared from our diet since most foods are completely devoid of these nutrients.
Fulvic acid is currently recognized as one of the necessary and essential compounds vital for flora, fauna, and also for human health.
Fulvic acid is found naturally in plants and humus containing soils, many of which have now disappeared from farms around the world due to overuse of soils and soil depletion.
Fulvic acid balances and energizes botanical cell life and animal and human cell life including the providing of essential electrolytes and other constituents upon contact. (ref.)
Doctors and scientists tell us that we require over 90 nutrients including vitamins, minerals, amino acids and essential fatty acids to maintain good health. Add to this list Fulvic acid as required by humans for optimal health.
Fulvic acid, as found in Mineral Pitch, can increase nutrient assimilation by enhancing bioavailability of nutrients. Fulvic acid is a life-giving compound necessary for the optimum health of all plants, animals, and humans. Fulvic acid helps to transport nutrients into the system and also detoxifies the body by chelating heavy metals and removing them from the body. Fulvic acid, as found in Mineral Pitch, is a very powerful antioxidant and free radical scavenger. Fulvic acid reacts with both negatively and positively charged unpaired electrons which helps to render free radicals harmless by altering them into new usable compounds or other inert compounds which will then be eliminated as waste. This activity affords the user more energy while strengthening the immune response mechanism. One way it happens is by improving the metabolism of proteins thereby enhancing DNA and RNA synthesis. Fulvic acid is a natural electrolyte that improves electrochemical balance of the body while increases activity of many enzymes and their associated systems. Fulvic acid may be used successfully for anti-microbial applications, burn healing, bone fracture healing, pathogenic suppression, skin conditions, venomous insect bites and plant induced skin irritations including many other associated applications.
Fulvic acid introduced with proper Humic acid supplementation to improve our depleted soil systems has an immense potential for soil and agricultural regeneration. Because our soils have become generally depleted by poor agricultural practices, human supplementation of fulvic acid from Mineral Pitch becomes a timely concern. Ancient soils before modern agricultural practices were once filled with natural deposits of Fulvic acid which is naturally generated by the activities of naturally occurring soil microbes and fungi that produce and deposit by their metabolic action small amounts of Fulvic acid. This process of Fulvic acid creation within the soil is very slow and is easily destroyed by modern farming fertilization and pesticide practices. Because of this situation our soils and thereby our food crops have become depleted of Fulvic acid and other important natural compounds, such as organic minerals. Because of this situation we do not automatically receive the beneficial supplementation of Fulvic acid or the vast array of essential minerals in our foods as we once did. Even, so-called “organic” soils are often absent from Fulvic acid. Unhealthy soils used for food crops = Unhealthy people.
Many efforts have been made to find a compound or natural material that can offer the best antioxidant solution for the necessity of free-radical scavenging. So far, there are some good products researched and implemented historically and contemporarily by a highly motivated health industry and so we now have good antioxidant products that help to combat free radicals such as Vitamin A, C, E, Gamma-Linoleic Acid, L-Cysteine, L-Glutathione, Selenium, and CoQ10, grape seed extract and others which are becoming more well known. Most of these are synthesized and some are natural. Mineral Pitch, containing Fulvic acid, Humic acid and other mineral components offers more free-radical scavenging action than all the above mentioned products taken together.
1. Agency for Toxic Substances and Disease Registry, Public Health Statements: Arsenic, Aluminum, Mercury, Zinc, Selenium, Cadmium, Lead.
2. Kehoe, R.A., et al.: Manganese, Lead, Tin, Aluminum, Copper and Silver in Normal Biological Material. J. Nutr. July 1940. Pages 85 – 98.
3. The Healing & Regenerative Influences of Low Molecular Weight Humic Substances (Fulvic Acid) On Human Tissues and Cells
4. The same transplant procedure without the fulvic acid showed no signs of regeneration during the course of the experiment.
5. Clinical tests and previous experiments, with Fulvic acid has been shown to activate and stimulate white blood cells, promote healing, turn inorganic calcium into an organic bio-active cellular regenerative medium conducive to new bone growth, stimulate cellular growth and regenerate, and inhibit HIV virus.
6. Animal Experiments with Fulvic acid
7. Early studies with livestock animals were conducted by Dr. Charles S. Hansen, D.V.M. in the state of California from the early 1960’s through 1967 on an experimental basis. Dr. Hansen’s test included a blend of fulvic and Humic acid used as a feed additive. He also used fulvic acid alone as a treatment for specific ailments in livestock. The results of supplement feeding and treatment included: Dairy Cows after 2 months of Fulvic acid supplement had no bacterial or viral infections. A herd of over 300, after 3 months on supplement increased butterfat production 15%. Herd on supplement cut back on high protein rations with no decrease in production. All cows on supplement experienced more complete digestion. Cows with bacterial infection (mastitis) treated with 1 pint fulvic acid solution recovered to full production in 12 to 24 hours. Successfully eliminated most diseases common to mink herds. The results of these early tests support the known benefits which fulvic acid provides.
1. Scenecsi, N (1990). Analytica Chmiica Acta, 232, 51-75. Amsterdam, The Netherlands Elscvier.
2. Powerful electrolyte – Jackson, William R (1993) Humic, Fulvic and Microbial Balance: Organic Soil Conditioning, 329. Evergreen, Colorado: Jackson Research Center.
3. Acidity of fulvic acid – Schnitzer, M 91977). recent findings of the characterization of Humic substances extracted from soils from widely differing climatic zones. Proceedings of the Symposium on Soil Organic Matter Studies, Braunsweig (117-131)
4. Environment with adequate oxygen – Schnitzer, M 91977). recent findings of the characterization of Humic substances extracted from soils from widely differing climatic zones. Proceedings of the Symposium on Soil Organic Matter Studies, Braunsweig (117-131)
5. Low molecular weight – Aiken, G.R., McKinght, D.M. & MacCarthy, P (1985). Humic substances of soil, sediment and water, New York: Wiley-Interscience.
6. Absorption by cells – Azo, S. & Sakai, I (19630. studies on the physiological effects of Humic acid. Part I. Uptake of Humic acid by crop plants and its physiological effects. Soil Science and Plant Nutrition, 9(3), 1-91. (Tokyo)
7. Effect on total Earth environment – Buffle, J. (1988). Complexation reactions in aquatic systems: An analytical approach. Chichester: Horwood.
8. Transmutate or synthesis of new minerals – Schnitzer, M., & Dodama, H. (1977). Reactions of minerals with soil Humic substances. In J.B. Dixon & S.B. Weed (Eds.), Minerals in soil environments (Chap. 21). Madison, WI: Soil Science Society of America.
9. Maximum stimulation of enzyme development – Jackson, William R. PhD. (1993) Humic, Fulvic and Microbial Balance: Organic Soil Conditioning. Evergreen, Colorado
10. Free radicals, Scncsi, N. (1990). Molecular and quantitative aspects of the chemistry of fulvic acid and its
11. U.N. Riede, Dept. of Pathology, University Hospital, Freiburg, Germany, J. Yu, Dept of Pathology, University Hospital, Freiburg, Germany. W. Ziechmann, Ground Chemistry Research Group, University of Gorrinfen, Germany. E.H. Kuner, Dept. of Surgery (Traumatology), University Hospital Freiburg, Germany. B. Seubert, Weyl Chemicals, Mannheim, Germany.
Bibliography to Fulvic Free Radical Data
1. Mowrey, Daniel B., PH.D. (1993), p. 34, Herbal Tonic Therapies. Keats Publishing, Inc.
2. Todd, Gary Price, M.D., (1985)., p.20-24, 113-118. Nutrition Health & Disease. Whitford Press.
3. Steelenk, C.A. & Tollin, G. (1962) p. 59, 25-34. Biochimica Biophysica Acta
4. Senesi, N Chen, Y. & Schmitzer, M. (1977). Soil Biology and Biochemistry.
5. Vaughan, D., Malcolm, R.B. & Ord, 13.G (1985) Soil Organic Matter & Biological Activity. Dordriecht, Netherlands: Martinus Nijhoff.
6. Jackson, William R., Ph. D. (1995). p. 261-282 Humic, Fulvic and Microbial Balance: Organic Soil Condition. Evergreen, Colorado.
Humic acid is another important compound found in Mineral Pitch. Humic acid, along with Fulvic acid, supports free-radical scavenging and antioxidant activities. Humic acid can acquire positive ions (free radicals) under one condition and release them when conditions change. It picks up ions depending on the availability of different ions to replace the one released. Positive ions are called cations and the pickup and release property is called cation exchange capacity. Humic acid holds cations so they can be absorbed improving micronutrient cellular exchange and transference to the bodies’ circulation system.
The formation of Humic substances in the soil (and in Mineral Pitch) is one of the least understood aspects of humus chemistry, but it is vital to the improvement of soil compositions, proper food production and human health. Studies on this subject are of long-standing and continued research can be justified on theoretical and practical grounds. Several pathways exist for the formation of Humic substances during the decay of plant and animal remains in soil.
Mineral Pitch, which represents ancient, rich soil constituents, contains significant amounts of naturally occurring Humic compounds.
(See above references for Fulvic acid}
MultiShroom™ is recommended as a daily supplement to support the optimal health of your brain, immune system and energy systems.
Our MultiShroom™ is flavored with chocolate concentrate and Monk fruit.